Tag: 夜上海论坛NT

  • Thinking ahead on diabetes

    first_imgDoctors may be able to identify individuals at elevated risk of developing type 2 diabetes as much as a decade before symptoms of the disorder appear by measuring the levels of small molecules in the blood.In a report in Nature Medicine, a team led by Massachusetts General Hospital (MGH) researchers describes finding that levels of five amino acids not only indicated increased diabetes risk in a general population but also could differentiate among individuals with traditional risk factors such as obesity those most likely to actually develop diabetes.“These findings could provide insight into metabolic pathways that are altered very early in the process leading to diabetes,” says lead author Thomas Wang, an MGH cardiologist and associate professor of medicine at Harvard Medical School (HMS). “They also raise the possibility that, in selected individuals, these measurements could identify those at highest risk of developing diabetes so that early preventive measures could be instituted.”New technologies to measure levels of metabolites — small molecules produced by metabolic activities and released into the bloodstream — are giving investigators more insight into the metabolic status of patients.  Because the diagnosis of type 2 diabetes marks the culmination of a years-long breakdown of the body’s system for metabolizing glucose, the ability to detect that breakdown at a stage when lifestyle changes could halt the process may significantly reduce the incidence of the disease.  Known risk factors such as obesity and elevated glucose levels often signify that diabetes actually is present, so earlier identification of at-risk individuals is critical to more effective preventive measures, the authors note.Some earlier studies had found elevated levels of certain amino acids in individuals who are obese or have insulin resistance, a condition that precedes full-blown type 2 diabetes.  But no previous study examined whether levels of these or other metabolites predicted the future development of diabetes in currently healthy individuals.The current study began with an analysis of data from the Framingham Offspring Study, which follows a group of adult children of participants in the original Framingham Heart Study.  Out of 2,400 study participants who entered the study in 1991 and 1995, about 200 developed type 2 diabetes during the following 12 years.Using the baseline blood samples, the research team measured levels of 61 metabolites in 189 participants who later developed diabetes and 189 others — matched for age, sex, and diabetes risk factors such as obesity and fasting glucose levels — who remained diabetes free.This analysis found that elevations in five amino acids — isoleucine, leucine, valine, tyrosine, and phenylalanine — were significantly associated with the later development of type 2 diabetes.  Several of these amino acids were the same ones that in smaller studies were found to be elevated in individuals with obesity or insulin resistance, and other evidence has suggested they may directly affect glucose regulation.  The association of levels of these five amino acids with future diabetes development was replicated in 326 participants in the Malmo Diet and Cancer Study.The investigators then found that measuring combinations of several metabolites, as opposed to a single amino acid, improved risk prediction.  Overall, in individuals closely matched for traditional risk factors for type 2 diabetes, those with the highest levels of the three most predictive amino acids had a four to five times greater risk of developing diabetes than did those with the lowest levels.“Several groups have suggested that these amino acids can aberrantly activate an important metabolic pathway involved in cellular growth or can somehow poison the mitochondria that provide cellular energy,” says senior author Robert Gerszten, associate professor of medicine at HMS and director of clinical and translational Research for the MGH Heart Center. “From a clinical perspective, we need to see if these markers, which we found using data from only about 1,000 individuals, do identify truly high-risk individuals who should be triaged to early preventive treatment and intensive lifestyle interventions.  Additional basic investigations can reveal if these metabolites play a role in the process leading to diabetes and if there are ways we can stop the damage.”last_img read more

  • Early Lead For Trojans Seals Fate For Bulldogs

    first_imgThe Bulldogs watched the game slip away early and couldn’t recover in a 12-7 loss to East Central on Thursday. East Central scored seven in the top of the first to secure the lead and Batesville never fully recovered.Batesville and East Central each had 13 in the high-scoring affair.Simon Williams earned the win for East Central. He lasted five innings, allowing eight hits and four runs while striking out six. Zach Henson and Gunnar Seig entered the game out of the bullpen and helped to close out the game in relief.Riley Zink took the loss for the Bulldogs. He allowed seven runs on four hits and walked one.Batesville launched one home run on the day. Quinn Werner went yard in the first inning.Trey Heidlage, Sam Voegele, Brayden Linkel, and Werner all managed multiple hits for Batesville. Heidlage led the Bulldogs with three hits in four at bats.The loss puts Batesville at 4-4 for the season and 2-2 in the conference. The Bulldogs will travel to Kentucky this weekend for the Doc Morris Invitational.Courtesy of Bulldogs Coach Justin Tucker.last_img read more

  • The Latest: Lakers GM Pelinka draws inspiration from Bryant

    first_imgHowever, it did not specify how much money the players themselves would be contributing.With the Premier League suspended indefinitely, players in England’s top flight have come under public pressure to cut their salaries to help clubs pay staff without using a government fund set up for the pandemic.___The NFL is turning the league’s 2020 draft into a three-day fundraiser to help six charities dealing with the coronavirus pandemic. The “Draft-A-Thon” announced Wednesday will benefit COVID-19 relief efforts and pay tribute to healthcare workers and first responders. ___Bobblehead Hall of Fame CEO Phil Sklar will present a virtual $100,000 check Wednesday afternoon to the Association for Healthcare Philanthropy after the Milwaukee-based museum launched a fundraising campaign with a Dr. Anthony Fauci bobblehead that became its best-seller ever. More than 20,000 orders had come in as of Wednesday from 50 states and a dozen-plus countries to support the “100 Million Mask Challenge.” The Fauci bobblehead was unveiled April 1.The creation features Fauci wearing a suit as he makes a motion showing how the nation needs to “flatten the curve” in the coronavirus pandemic.The museum picked Fauci because many people see the plain-speaking expert on the coronavirus as a hero right now, Sklar said. The Latest: Lakers GM Pelinka draws inspiration from Bryant The London-based Tennis Integrity Unit’s quarterly report says it received a total of 38 alerts from the regulated betting industry about matches on lower-level tours from the start of the year through March 22.That is up from 21 in the same period of 2019.The 38 match alerts in the year’s first quarter break down as six from the ATP Challenger Tour and 16 apiece from the men’s and women’s International Tennis Federation World Tennis Tours.The report concludes the jump indicates that entry levels of tennis “were deliberately targeted” as the sport moved toward suspension because of the outbreak of COVID-19.All pro tours are on hold until at least mid-July. The Italian Olympic Committee says Donato Sabia has died. He was 56.CONI says he is the first Italian Olympian to die with the virus.Sabia finished fifth in the 800 at the 1984 Los Angeles Games and seventh at the 1988 Seoul Games. He also won the 800 at the 1984 European Indoor Championships.Sabia died in his hometown of Potenza in southern Italy shortly after his father also died from the virus.___ ___The players and coach on Switzerland’s national soccer team have declined to take more than 1 million Swiss francs ($1.03 million) of payments that were due from their federation in 2020.The team was scheduled to play in the now-postponed European Championship in June and had two games in Qatar canceled last month because of the coronavirus pandemic.The shutdown of games has cost the Swiss soccer body millions of dollars.Federation chairman Dominique Blanc says it’s a “magnificent gesture” from the players. Barcelona and Atlético Madrid had already requested government furloughs to reduce labor costs. They reached agreements with players to reduce their salaries by 70%.The league said Tuesday eight teams had already requested the furloughs. It expected nearly all clubs in Spain to eventually reach agreements for the reduction of salaries of their players.The Spanish league estimates $1 billion euros ($1.1 billion) in losses if the competition can’t resume.___Former French rugby player Christophe Pras has died after getting infected by the coronavirus. ___A groom who worked at Belmont Park has died from complications of coronavirus.The New York Racing Association says Martin Zapata died Tuesday. The 63-year-old native of Panama had spent the past two years working for trainer Tom Morley in New York, which has been hard-hit by the pandemic.NYRA says Zapata tested positive for COVID-19 on March 24 and was hospitalized two days later. He lived and worked at Belmont Park.___ Pelinka was Bryant’s longtime agent before he took over the Lakers’ front office this season. The executive has been thinking of Bryant constantly since his death along with his daughter, Gianna, who was Pelinka’s goddaughter.With an uncertain future ahead for the Lakers and the NBA, Pelinka has been imagining what Bryant would say.“If you were on a knight’s journey with him and a huge fire-breathing dragon ended up in the pathway ahead, he could say, ‘OK, you know, this is why this is good right now,’” Pelinka said in a conference call with local reporters Wednesday. “We’re going to meet this challenge. Here’s how we’re going to get around it, and here’s how we’re going to defeat it.’ That was just his nature, that obstacles or hard times would lead somehow to growth. And I think that that’s the way I’m going to look at 2020, not just in terms of the loss of Kobe but just in general.”Pelinka also spoke about the previously reported decision of several top Lakers executives to take a voluntary pay deferral during the health crisis. Sevilla has become the latest Spanish soccer club to put its players on furlough to reduce labor costs during the coronavirus pandemic.The club says the measure was needed because it was significantly affected financially by the stoppage of competitions in Spain and Europe.It says it reached an initial agreement with the first-team players and coaches regarding their salaries but no details were immediately released.The club says 360 employees in total will be affected. It says workers who can continue doing their jobs remotely will not go on furlough.The current contracts will remain valid after the furloughs end. ___The NFL’s Arizona Cardinals are teaming with State Farm to donate 1 million meals to local food banks to help families during the new coronavirus crisis.The team said on Wednesday that the number of people seeking help from local food banks has more than doubled while the number of donations has decreased dramatically.The Cardinals have already made a $1 million donation to the Arizona Coronavirus Relief Fund and organized three blood drives at State Farm Stadium to help boost the area’s shrinking blood supply. Cardinals coach Kliff Kingsbury was among those who donated blood.___ Several of his former clubs announced the death. He was 35.The former under-18 France international had a short-lived professional career before going into coaching.Pras is survived by his wife and two children.___The group charged with monitoring tennis gambling and punishing corruption found a near-doubling in the number of suspect matches in the first three months of 2020. That is an increase it ties to the coronavirus pandemic. April 8, 2020 Former Cleveland Browns teammates Joe Thomas and Andrew Hawkins have donated at least $50,000 to feed Ohio children affected by the coronavirus pandemic.Thomas and Hawkins, who since retiring from the NFL have partnered on a popular weekly podcast, also plan to match every dollar in contributions up to $50,000 to the Children’s Hunger Alliance.Donations can be made at https://childrenshungeralliance.org/thomahawk/.The CHA serves nutritious meals to Ohio’s at-risk children, helping day care providers, day care centers, local school districts, and after-school and summer programs.A 10-time Pro Bowler, Thomas played 11 seasons in Cleveland before retiring after the 2017 season. Hawkins, who played college ball at Toledo, spent three seasons with the Browns and three with the Cincinnati Bengals. Associated Press center_img The fundraiser will be featured during the draft April 23-25 to raise money for non-profits selected by the NFL Foundation: the American Red Cross, CDC Foundation’s All of Us, Feeding America’s COVID-19 Response Fund for member food banks, Meals on Wheels COVID-19 Response Fund, the Salvation Army, and United Way’s COVID-19 Community Response and Recovery Fund. “The Draft-A-Thon will deliver much-needed funding to many who are suffering as well as those on the front lines of the COVID-19 pandemic,” Commissioner Roger Goodell said in a statement. “Conducting this event virtually, and taking all necessary precautions while doing so, underscores the importance of staying home and staying strong during this unprecedented moment in our history.”___Basketball Hall of Famer and noted cyclist Bill Walton is teaming with community leaders to stage the Bill Walton and Friends Inter-Galactic Bike for Humanity ride from 9-11 a.m. PDT on April 25 to benefit victims of the coronavirus pandemic and health care workers. The opening of the stable area and training track at Saratoga in upstate New York and barn area at Monmouth Park in New Jersey is being delayed because of the coronavirus pandemic.The Oklahoma training track at Saratoga was set to open April 15. The New York Racing Association says it has yet to decide an appropriate date to safely open.The delay does not impact the start of the Saratoga racing season which is scheduled to begin on July 16 and run through Sept. 7. The meet will be highlighted by the Travers and Whitney.In New Jersey, Monmouth Park has pushed back the opening of its stable area until June 1. That’s a month later than the planned opening. Live racing is set to start the Fourth of July weekend.The centerpiece of Monmouth Park’s summer season is the $1 million Haskell Invitational on July 18. The winner of the 1 1/8 mile race earns a spot in the Breeders’ Cup Classic. It also will serve as a prep race for the Kentucky Derby, now slated for Sept. 5. Share This StoryFacebookTwitteremailPrintLinkedinRedditThe Latest on the effects of the coronavirus outbreak on sports around the world:___Los Angeles Lakers general manager Rob Pelinka is drawing inspiration from his friendship with Kobe Bryant as he navigates the coronavirus pandemic. Participants are encouraged to ride their bikes for up to two hours that day, anywhere they can practice social distancing at a minimum of 6 feet, 11 inches, in honor of Walton’s height. Organizers stress it is not a group ride and riding clusters are prohibited.All net proceeds will benefit various charities nationally and in Walton’s hometown of San Diego.It’s free to sign up on bikeforhumanity.com. Participants who make a $25 contribution will be mailed a Bike for Humanity medal. Those who contribute $50 will receive a medal and T-shirt. Those making a $250 contribution will receive a medal, T-shirt and autographed photograph card from Walton, and be entered in a drawing for prizes, including an all-expenses-paid trip to San Diego to ride with Walton. Riders who donate $5,000 will receive a medal, T-shirt and an all-expenses paid trip to San Diego to ride with Walton.Beset by injuries during his NBA career, Walton has found an outlet by cycling. His custom bike has a Grateful Dead paint job and the former UCLA great can often be seen riding around San Diego. He has often ridden in various stages of the Tour of California.“With the global health coronavirus crisis changing everything for everybody these days, we are doing something about and for the exacerbated challenges that so many of our communities now face, not the least of which are food and medical care,” Walton said. The Spanish league has estimated that clubs will lose a combined $1 billion euros ($1.1 billion) if the competition can’t resume because of the pandemic.___Premier League players have united to raise funds for British health care workers during the coronavirus pandemic and distribute them “where they are needed most.”Dozens of players took to social media to post a statement with the hashtag #PlayersTogether saying they have created the initiative in partnership with charities for Britain’s public health service NHS.The statement said “this is a critical time for our country and for our NHS, and we are determined to help in any way that we can.” CEO Chase Carey will take a “much deeper” pay cut.The McLaren and Williams teams had already put some staff on furlough schemes. McLaren drivers Lando Norris and Carlos Sainz have also taken pay cuts.The season is currently scheduled to begin in France on June 28. F1 management has said it still hopes to hold between 15 and 18 races this year in place of the original 22.___A two-time Olympic finalist in the 800 meters has died after getting infected with the coronavirus. “I would be in support of anything that allows people to keep their jobs in really hard times,” he said.___Real Madrid’s players and coaches have agreed to voluntarily reduce their salaries by at least 10% to help offset lost revenue caused by the coronavirus pandemic.The club said the decision applied to its soccer and basketball teams. Some top club executives have agreed to take pay cuts that could reach 20% “depending on the circumstances that may affect” the rest of the season.Fellow Spanish league club Sevilla also said Wednesday it would put its players and other employees on government furloughs to reduce labor costs during the pandemic. Barcelona and Atlético Madrid had already requested the government furloughs, reaching agreements with players to reduce their salaries by 70%. Parsons says the problem was due partly to broadcast rights holders who want to delay their payments until the product is delivered.Parsons says it’s not a question of “losing money” but rather some temporary belt tightening.He says “like all businesses we are tremendously affected by the COVID-19 crisis.”He says he is dealing with 150 contracts that are games-related but adds “we have no plans to let any staff go at the moment.”___ ___TCU football coach Gary Patterson and his wife, Kelsey, made a $50,000 donation to support the school’s Frog Family Crisis Fund.Athletic director Jeremiah Donati announced the donation in a tweet. The fund supports TCU students and their families who are in need during times such as the current pandemic.Patterson is the second-longest tenured FBS head coach, going into his 20th season next fall leading the Horned Frogs. He was their defensive coordinator three seasons before that.___ World Athletics has also postponed the bidding processes for 2023 World Athletics Series events. They will now open in November 2020.___Formula One says it will furlough half of its staff until the end of May and senior executives will take pay cuts amid the coronavirus pandemic.F1 has postponed eight races so far this season and the Monaco Grand Prix has been canceled.F1 says senior leadership figures will take “voluntary pay cuts while still continuing to work and not in furlough.” The track world championships in Eugene, Oregon, have been rescheduled for July 15-24, 2022.The event was pushed back a year because the Tokyo Olympics were delayed until 2021 amid the coronavirus pandemic.The track worlds were originally scheduled for Aug. 6-15, 2021.World Athletics president Sebastian Coe says 2022 will be a “bonanza for athletics fans around the world” with the Commonwealth Games beginning in Birmingham, England, only three days after the track worlds.The 2022 Commonwealth Games are scheduled for July 27-Aug. 7 and the multi-sport European Championship is currently slated for Aug. 11-21 in Munich. Blanc tested positive for the virus three weeks ago.Team captain Stephan Lichtsteiner says “we wanted to set an example and show solidarity.”___The president of the International Paralympic Committee says the body has “cash-flow” problems because of the Olympic and Paralympic postponement until 2021.Andrew Parsons says about 5% of spending is being cut from the IPC’s budget. A 2018 financial report showed a budget of 24 million euros ($25.7 million). More AP sports: https://apnews.com/apf-sports and https://twitter.com/AP_Sports,Tampa Bay Lightning advance to face Dallas Stars in Stanley Cup finals, beating New York Islanders 2-1 in OT in Game 6last_img read more

  • USC-Stanford Live Blog

    first_imgToday’s game kicks off at 5:00 on the West Coast.  All updates will be timestamped with game time. Be sure to check out our Twitter feed for instant info at http://www.twitter.com/dailytrojan6:54 4th Quarter. Stanford 34-28.USC is unable to score on the drive following Stanford’s touchdown. The offense hasn’t been able to get its running game going much but Barkley has been doing well. He completed to big third down passes on that drive, but stalled at the Cardinal 33 yard line when his passes on 3rd and 4th down fell incomplete down the left sideline looking for Johnson. The defense now has to do something it hasn’t done all half, stop the Stanford offense.11:11 4th Quarter. Stanford 34-28.TOUCHDOWN USC! The Trojans tie the game on a 6-yard pass by Barkley to Woods in 4th and 2. USC lined up with everyone on the line of scrimmage and Barkley play-actioned to Bradford before throwing off his backfoot to a wide-open Woods. The Trojans were stuffed on 3rd and 1 when Tyler got the carry instead of Bradford.However, on the ensuing kickoff Stanford returned it to the Trojans 9 yard line and three plays later, Luck found a wide-open Doug Baldwin on a 7-yard pass across the middle for a STANFORD TOUCHDOWN. The Cardinal missed the extra point.14:51 4th Quarter. Stanford 28-21.Touchdown Stanford. Luck threw a 2-yard pass to tight-end Konrad Reuland after scrambling for a while to extend the play. The Cardinal drove 82-yards down the field in just 6 plays, but were helped by the Trojans. In what has been a theme of this game, on 3rd and 4, Luck completed a 29-yard pass to Wilkerson to get down to the USC 33 yard line and then on the next play completed a 25-yard pass down to the 8.USC then committed another pass interference penalty in the end zone on a Shareece Wright interception and then Luck threw the touchdown. That makes it twice USC bailed Stanford out and committed a pass interference penalty in the end zone on a pass that wasn’t going to be complete. The defense needs to stop the Cardinal on third down and no shoot itself in the foot. This game could come down to who gets the ball last.2:59 3rd Quarter. 21-21.TOUCHDOWN USC! Robert Woods catches a pass wide open across the middle and makes a beautiful move to juke out a defender before racing 61 yards down the sideline for the score. The freshman now has 9 catches for 200 yards and I have a feeling he’s not done. The offense needed just five plays for the score, but it took a third down conversion when Barkley hit Johnson on a short out route for the 1st down. If the defense can get a stop or turnover here, that would be big for the Trojans.A few note on defense: Junior Shane Horton has been playing for Malcolm Smith at linebacker this half (and most of the first half) because it appears Smith is injured. Junior Chris Galippo is also getting a lot of playing time at middle linebacker for Devon Kennard. Could this be the change the defense needed? Defensive end Wes Horton is out for the second game in a row.5:39 3rd Quarter. Stanford 21-14.Touchdown Stanford. The Cardinal cap a 14-play, 92 yard drive with a one-yard dive over the top by Stepfan Taylor. The Trojans appeared to stop the Cardinal on their six yard line when a pass from Luck fell incomplete in the end-zone, but a pass interference penalty was called and Stanford got three more cracks. The defense has played better than it has all year at times, but it allowed multiple third-down conversions. We’ll see if the offense, which punted on its opening possession can counter.14, 92Halftime. 14-14.It’s halftime here at Stanford Stadium and it’s been about the big plays. When Stanford has gotten it’s running game going, it’s had very little opposition. But give credit to the Trojan defense for coming up with some big plays. The defense has stuffed Stanford a few times on third down and has forced two fumbles (both of which we recovered) after forcing just one through the first five games.As far as the offense is concerned, it’s operating okay but there’s been some questionable play calling from Kiffin. Kiffin decided to run the ball with 20 seconds left when the Trojans had 2 timeouts and the ball at the Stanford 40 yard line. Needless to say, the Trojans didn’t get any points on the final drive. Freshman receiver Robert Woods is the star of the first half, 7 catches for 117 yards and one touchdown. He is lighting up the Cardinal. Barkley is looking fine and Bradford is running over people. As long as the offense stays turnover free it should be able to stick with Stanford. The USC defense has shown at times it can be tough and has played its best football of the year, but other times it looks terrible. Hopefully for the Trojans, they can get that sorted out for the second half.8:33 2nd Quarter. Stanford 14-7.Touchdown Stanford. Sorry there’s spotty internet access up here. Cardinal running back Anthony Wilkerson runs to the right for a six-yard touchdown run. It’s too easy for Stanford to run the ball down the field. The USC defense has missed so many tackles after an impressive first series, and then a sack/fumble by Nick Perry. But the Trojans gave it right back when Baxter handed off to fullback Stanley Havili inside the redzone who subsequently fumbled it. The only way it appears USC can win this game is if it can score with Stanford.8:17 1st Quarter. USC 7-0.TOUCHDOWN USC! Freshman running back Dillon Baxter gets his first touchdown with a 8-yard touchdown run out of the wildcat formation. After much hype, Baxter struggled early and admitted this week that he wasn’t giving 100 percent effort thus far. But he said the three practices this week were his three best practices and it just showed. Last week, Marc Tyler got the majority of the carries out of the wildcat but coach Lane Kiffin is showing faith in the freshman.Baxter’s touchdown run comes after a methodical drive by the Trojans where they mixed short passes, runs with Allen Bradford and one long sideline pass to Brice Butler. USC got the ball when it stopped Stanford on three-and-out on its first series, something that has rarely been seen this year from the Trojan defense. Linebacker Malcolm Smith made a tackle in the backfield on third-and-one.  Strong start by the Trojans.40 mins to kickoff- Hey guys, Kenny here and we are getting ready for this matchup of 5-1 teams. Both teams are coming off of a tough loss and don’t want to start Pac-10 play 1-2. Stanford is the favorite, but USC still should never be counted out. It’s a beautiful day here in Palo Alto, 77 degrees with a slight breeze. Perfect football weather. There’s a bunch of USC fans (mostly students) here for the weekender and they have been tailgaiting a long time and ready to see USC come out with the victory. Should be a great game. Stay tuned for more info.last_img read more

  • TUNA CAUGHT OFF DONEGAL ISN’T THE BIGGEST EVER

    first_imgA TUNA landed in Killybegs isn’t the biggest ever landed off the coast of Donegal.There were claims three days ago that the 500lb fish was the biggest ever.The biggest was caught three years ago – and weighed 900lbs. Ends TUNA CAUGHT OFF DONEGAL ISN’T THE BIGGEST EVER was last modified: February 11th, 2012 by BrendaShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window)last_img read more