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  • Thinking ahead on diabetes

    first_imgDoctors may be able to identify individuals at elevated risk of developing type 2 diabetes as much as a decade before symptoms of the disorder appear by measuring the levels of small molecules in the blood.In a report in Nature Medicine, a team led by Massachusetts General Hospital (MGH) researchers describes finding that levels of five amino acids not only indicated increased diabetes risk in a general population but also could differentiate among individuals with traditional risk factors such as obesity those most likely to actually develop diabetes.“These findings could provide insight into metabolic pathways that are altered very early in the process leading to diabetes,” says lead author Thomas Wang, an MGH cardiologist and associate professor of medicine at Harvard Medical School (HMS). “They also raise the possibility that, in selected individuals, these measurements could identify those at highest risk of developing diabetes so that early preventive measures could be instituted.”New technologies to measure levels of metabolites — small molecules produced by metabolic activities and released into the bloodstream — are giving investigators more insight into the metabolic status of patients.  Because the diagnosis of type 2 diabetes marks the culmination of a years-long breakdown of the body’s system for metabolizing glucose, the ability to detect that breakdown at a stage when lifestyle changes could halt the process may significantly reduce the incidence of the disease.  Known risk factors such as obesity and elevated glucose levels often signify that diabetes actually is present, so earlier identification of at-risk individuals is critical to more effective preventive measures, the authors note.Some earlier studies had found elevated levels of certain amino acids in individuals who are obese or have insulin resistance, a condition that precedes full-blown type 2 diabetes.  But no previous study examined whether levels of these or other metabolites predicted the future development of diabetes in currently healthy individuals.The current study began with an analysis of data from the Framingham Offspring Study, which follows a group of adult children of participants in the original Framingham Heart Study.  Out of 2,400 study participants who entered the study in 1991 and 1995, about 200 developed type 2 diabetes during the following 12 years.Using the baseline blood samples, the research team measured levels of 61 metabolites in 189 participants who later developed diabetes and 189 others — matched for age, sex, and diabetes risk factors such as obesity and fasting glucose levels — who remained diabetes free.This analysis found that elevations in five amino acids — isoleucine, leucine, valine, tyrosine, and phenylalanine — were significantly associated with the later development of type 2 diabetes.  Several of these amino acids were the same ones that in smaller studies were found to be elevated in individuals with obesity or insulin resistance, and other evidence has suggested they may directly affect glucose regulation.  The association of levels of these five amino acids with future diabetes development was replicated in 326 participants in the Malmo Diet and Cancer Study.The investigators then found that measuring combinations of several metabolites, as opposed to a single amino acid, improved risk prediction.  Overall, in individuals closely matched for traditional risk factors for type 2 diabetes, those with the highest levels of the three most predictive amino acids had a four to five times greater risk of developing diabetes than did those with the lowest levels.“Several groups have suggested that these amino acids can aberrantly activate an important metabolic pathway involved in cellular growth or can somehow poison the mitochondria that provide cellular energy,” says senior author Robert Gerszten, associate professor of medicine at HMS and director of clinical and translational Research for the MGH Heart Center. “From a clinical perspective, we need to see if these markers, which we found using data from only about 1,000 individuals, do identify truly high-risk individuals who should be triaged to early preventive treatment and intensive lifestyle interventions.  Additional basic investigations can reveal if these metabolites play a role in the process leading to diabetes and if there are ways we can stop the damage.”last_img read more

  • UK roundup: ITV in discussions over contingent asset deal

    first_imgITV is in discussions with its pension scheme trustees over the potential sale of London Television Centre, which was pledged to the scheme as a contingent asset in 2014.In a third-quarter trading statement published yesterday, the UK broadcaster said it was negotiating with trustees of the £3.9bn (€4.5bn) scheme regarding the provision of a “suitable equivalent asset”.“The proceeds of the sale of the South Bank site could be used to replace the £50m asset security and to reduce ITV’s net debt position,” the company stated.ITV also reported a net surplus of £9m for its defined benefit (DB) arrangements as of 30 September. This marked a £77m fall in the surplus from the end of June. BNY Mellon has secured its position as custodian for RPMI Railpen, one of the largest pension funds in the UK.It was reappointed after a competitive tendering process, according to a press release. It has been a provider to the £28bn multi-employer scheme for 22 years.Paul Nathan, chief operating officer at RPMI Railpen, said: “Through a major transformation programme at Railpen, as we bring significant asset management capability in-house, BNY Mellon has demonstrated not only the quality of its service proposition but also its flexibility and professionalism.“A robust operating model is essential to ensuring that Railpen continues to meet its mission to pay pensions, securely, affordably and sustainably. We are very pleased BNY Mellon will be supporting us with this over the coming years.” The company’s contribution schedule was agreed based on a 1 January 2017 valuation, when the scheme had a £470m shortfall. As such, ITV said it expected to contribute roughly £80m to the pension scheme this year and £75m next year.DB consolidator appoints service providers ahead of launchClara Pensions, a commercially backed consolidator for UK DB pension schemes, has appointed several third-party service providers as it prepares to reveal its first clients.Consultancy group Hymans Robertson has been appointed as the company’s actuarial adviser, having been advising the Clara team on several areas since the beginning of 2018.Eversheds Sutherland has been chosen as legal adviser to the company’s independent trustees, while CMS will continue as Clara Pensions’ legal adviser, a role it has had since last year. Ross Corporate Services, a London-based governance specialist, has been named as scheme secretary.RPMI Railpen reappoints BNY Mellon as custodianlast_img read more


    first_imgBuncrana GAA Notes For Week Ending Sunday 12th AugustCongratulations: Many Buncrana Gaels made the journey south to the capital at the weekend to witness an historic victory for Donegal over Kerry. Ryan Bradley again deserves great credit for his hardworking performance in the middle of the field and will be delighted to have another All-Ireland Semi-Final to prepare for. Congratulations to Ryan and the entire squad. Senior Ladies Football: Our senior ladies football team had to travel to Termon on Sunday last for their second leg first round championship match. After suffering a very close defeat at the hands of Termon in the first leg of this fixture just a few weeks ago, the girls were determined that this was not going to the their last championship match of the season, and boy did they do it in style. After getting off to a bit of a shaky start and putting their first few scoring chances wide, the girls soon settled into the game and once Doreen McGee put the first point over, the entire game went Buncrana’s way. Termon did rally forward as much as they could but could never find away through to put anything on the scoreboard, with Claire Doherty pulling off some great saves in the Buncrana goal and the defense withstanding any attack. The Buncrana ladies came in at half time well in control of the game winning 2-3 to Termon’s 0-0. The second half continued in much the same vein as the first with Buncrana controlling all the play everywhere on the pitch. The girls’ confidence has come some way from their first ever match for the club, with them being able to quickly move the ball from player to player all the way up the field from full back line to midfield to full forward line. Termon put in a good effort, making some changes to the team with substitutions and a bit of shuffling the pack,but the Buncrana girls where ready for everything that was asked of them. Every girl there in a Buncrana jersey played their part in this wonderful win, right from the goalkeeper and onto the subs bench, as all the girls got a run out in this game. The double substitution of Ciara Barber and Danielle Kelly made their own mark on the game. with Danielle receiving the ball and laying it of quickly and accurately to Ciara who split the posts with her score. The Buncrana ladies came home victorious with a 5-9 to 0-2 win. U6 FUNdamentals: FUNdamentals for boys and girls aged 5 & 6 years (or turning 5 during 2012) will continue on Fridays at the Scarvey between 6.15pm and 7.00pm. Please could all children be accompanied by an adult for the duration of the session.U10 Football: Training continues every Friday at 7.00pm at the Scarvey and new players are always welcome.Boys U14 Hurling: Boys U14 Hurling training takes place at the Scarvey every Tuesday and Thursday evening at 7.00pm. If you haven’t played before and are interested in playing Hurling please feel free to come along.Boys U14 Football: Training for the boys U14 team will take place on Monday evening at 5.00pm. New and returning players are always welcome.Boys U14 & U18 Hurling: Hurling training for boys aged 14 to 18 years takes place every Saturday at the Scarvey at 3.00pm-5.00pm. New players are always welcome.U8 and U10 Hurling: Hurling training for children under 8 and under 10 years takes place each Sunday at 11.00am. If your child would like to learn the basic skills of hurling in a safe and fun environment please come down and try it out, new players are always welcome.Lotto: The winning numbers in the €2,960 jackpot lotto draw, which took place on Tuesday 31st July in O’Flaherty’s Bar on the Main Street, are as follows: 7-26-27-31. There was no jackpot winner this week, however there were five €20 prizes which went to the following lucky participants:James Molloy, 25a Burwood Christina Cuffe, 20 SummerhillKevin Hegarty, LisowenFaye McColgan, Upper SlaveryNatasha Craig, 20 Doonwood Congratulations to our winners and thank you to all for your continued support, it is very much appreciated.Club Notes: Anyone who would like to receive a copy of the weekly club notes should email Oisín at [email protected] to be included on the mailing list. If you have any items which you think should be included in the club’s weekly notes, please email Oisín at [email protected] by 6pm on each Sunday for consideration. To keep up to date with all the latest goings-on, please join us on www.facebook.com/buncranagaa or www.twitter.com/buncranagaaOisín DohertyPRO CLG Bun [email protected] NEWS: BUNCRANA CLUB NOTES was last modified: August 7th, 2012 by StephenShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window)Tags:buncrana gaa club noteslast_img read more