Tag: 夜上海论坛UD

  • Healing Brain Injuries

    first_imgResearchers at the University of Georgia’s Regenerative Bioscience Center have succeeded in reproducing the effects of traumatic brain injury and stimulating recovery in neuron cells grown in a petri dish.This makes them the first known scientific team in the country to do so using stem cell-derived neurons. The procedure, detailed in a new paper in Nature Scientific Reports, has significant implications for the study and treatment of such injuries.Unlike other cells in the body, most neurons in the central nervous system cannot repair or renew themselves. Using glutamate, an agent that is released in high amounts in the brain after traumatic injury, the research team recorded a concussionlike disruption of neural activity in a dish containing dozens of minute electrodes. Through these recordings, they then evaluated the activity and influenced recovery by electrical stimulation.“Once the neurons reach a certain level of density in the dish, you begin to see what we call synchronous activity in a very timed manner,” said lead author Lohitash Karumbaiah, assistant professor in University of Georgia’s College of Agricultural and Environmental Sciences Department of Animal and Dairy Science. “Knowing we could recreate synchronized, brainlike activity in a dish gave us the impetus to ask, ‘What if we disrupt this rhythm, and how can we recover from something like that?’”In 2015, the U.S. Food and Drug Administration approved the first deep-brain stimulation device — an electrical stimulation cap that patients wear continuously — for treatment of Parkinson’s disease. Karumbaiah and his team hope that electrical stimulation could be a clinically translatable approach for recovery from traumatic brain injury, or TBI. The next step, he said, is to connect with external collaborators to tailor electrical stimulation approaches with biomaterials that can exploit neuroplasticity.Such treatments could be highly beneficial, for example, to veterans. Many veterans suffer from TBIs incurred through shock waves from explosions, with no physical focal point of injury. “Drilling into the brain randomly to access tissue in such cases makes no sense,” said Karumbaiah. “A wearable device that can administer fairly controlled levels of relevant electrical stimulation can help these patients.”One of Karumbaiah’s co-authors is Maysam Ghovanloo, professor of electrical and computer engineering at the Georgia Institute of Technology. Ghovanloo has led the development of the Tongue-Drive System, which allows individuals with spinal cord injuries to control their wheelchair or digital devices by moving their tongue. He has also developed technologies for neural interfacing and implantable medical devices. Ghovanloo will put his expertise in medical instrumentation to work in developing devices for the team’s preclinical studies.“We have developed a unique approach for observing and guiding stimulatory patterns in the brain at multiple levels, all the way from individual neurons to the neural tissue, and eventually the entire brain,” Ghovanloo said. “All while taking into account the animal behavior to opportunistically apply stimulation when they are most effective.”According to Karumbaiah and Ghovanloo, electrical stimulation devices, whether designed for implantation or wearable use, must be small and power-efficient. They believe their approach will be clinically practical because smart design and application of stimulatory regimens can significantly reduce power consumption. ““Because we’ve been recording from these neurons for a long time, we know what the magnitude of the pulses or activities of these neurons are,” said Charles-Francois Latchoumane, a postdoctoral researcher in Karumbaiah’s lab. “Now we can mimic those routines by programming them externally and feeding it back into the brain.”For more information about the UGA Regenerative Bioscience Center, visit rbc.uga.edu.last_img read more

  • PCP: Worst ballpark

    first_imgPoppyThere are plenty of horrible ballparks out there to choose from — Shea Stadium, Tropicana Field and the Metrodome, among others. But the worst of them all is the Ball Park itself. The Ball Park brand hot dog, that is.First off, it is a cheap hot dog. Anybody who buys into the “Plump when you cook ’em!” slogan doesn’t know his doggies. They explode when you cook ’em!The now-famous Fourth of July hot dog-eating contest doesn’t offer its contestants Ball Park hot dogs for a reason. I’m not sure Kobayashi would still be standing if he were to down 53 3/4 Ball Park hot dogs instead of Nathan’s.However, the Ball Park is distasteful for several other reasons.For starters, the Ball Park first became popular in the city of Detroit. The Motor City isn’t exactly the ideal place for any culinary product to come from. Detroiters make cars, not food.Furthermore, its most recent spokesperson was Michael Jordan. Now, no disrespect to His Airness, but a hot dog product could find a much better spokesdog. A hot dog represents the game of baseball, and Jordan certainly didn’t represent baseball very well in his short-lived basketball vacation with the Barons. A .202 average and 11 errors would make Chuck Knoblauch proud, but not much anybody else. Plus, Jordan should know better. He played his basketball career in Chicago — he should know what a real hot dog tastes like. Ball Park must’ve paid Jordan a bunch of dough to shush about its sub-par pork product. His face should be slapped all over the Portillo’s Hot Dogs Restaurant in the Windy City, not a cheap product you could pick up at Aldi’s.While I wouldn’t be thrilled to be stuck in Dolphins Stadium for a Marlins’ game, I’d much rather do that than indulge in a Ball Park hot dog.McGrathShea Stadium has long been considered the Richard Simmons of Major League Baseball stadiums, looking not just ugly, but goofy and old. However, this past week has made it very clear that the worst ballpark in the majors lies not off the Atlantic, but off another major, much more radioactive body of water: Lake Erie. Of course, I am referring to the new mistake by the lake: Jacobs Field in Cleveland. The biggest problem with Jacobs Field is that it is right now more of a ski resort than a ballpark, with two feet of standing snow currently residing in the stadium.Snowmen currently constitute the bulk of the facility’s tenants, closely followed by snow angels. As polite and evenly constituted as snow statues and cherubs are, they are poor fans for baseball, mainly because the sport does not respond well to the conditions necessary to keep the tenants from becoming puddles. Also, while snowball fights can be very amusing and are often entertaining to watch, it’s unlikely that the good people of Cleveland will fill Jacobs Field to witness a contest of the 1st Avenue boys taking on the kids on 10th Street. However, while Jacobs Field is not always under 24 inches of snow, it still is an easy choice as worst venue in baseball, since the team itself does not even like playing there. When it came time to film Major League, the Indians chose to go to Milwaukee and be filmed at County Stadium — no beauty pageant winner itself — and borrow the Brewers’ announcer Bob Uecker for their own. Although Jacobs Field was not around at the time, you are borrowing from the Brewers for success… It’s bad news.Point: Jacobs Field.last_img read more

  • Operation Christmas Child Recipient Tells His Story of Receiving Shoebox

    first_imgAddThis Sharing ButtonsShare to FacebookFacebookShare to TwitterTwitterShare to MoreAddThisOver the years, many Alpena residents have participated in Operation Christmas Child. The global project shares the joy and meaning of Christmas with millions of boys and girls through one thing, a shoebox.Back in 1992 shoeboxes were sent to Uganda, one of those boxes landed in the hands of an 8-year-old boy named Bonny Kibuuka. Now 26-years-old Kibuuka is sharing his story.Items placed in the shoebox speaks to each child in different ways. The Alpena area packed over 2,500 shoeboxes last year. The boxes traveled to Madagascar and back to Uganda. Operation Christmas Child only serves ages 2 to 14 and the reason why is devastating, and that’s why Kibuuka encourages volunteers.AddThis Sharing ButtonsShare to FacebookFacebookShare to TwitterTwitterShare to MoreAddThisContinue ReadingPrevious Thomas Stafford Dog Park officially open in downtownNext ‘We have a good time’ at Labor Day Show in Tawaslast_img read more

  • Grayson Allen ejected from Summer League game after two flagrant fouls on Grant Williams

    first_imgGrayson Allen found himself back in the spotlight Thursday night in Las Vegas — for all the wrong reasons.The Grizzlies guard, who was sent to Memphis as part of the Mike Conley trade, was ejected in the fourth quarter of his team’s NBA Summer League game against the Celtics after committing two flagrant fouls on Boston rookie Grant Williams. Allen seemed to take exception to multiple (legal) screens set by Williams, and he retaliated with a couple cheap shots aimed at Williams’ head. SUMMER LEAGUE: How to watch every game in Las Vegas Allen left the Thomas and Mack Center with a confused look on his face, but there really isn’t any controversy here. The contact was unnecessary on both plays. (By the way, these two flagrant fouls happened in an eight-second span of game time.)Grayson Allen’s first flagrant, for those asking pic.twitter.com/KO9vgPGaSX— Paid man gets bored (@cjzero) July 12, 2019Grayson Allen gets his 2nd flagrant in about 3 minutes and gets ejected and Dan Dakich is fed the hell up pic.twitter.com/SY5sEXX6fc— Paid man gets bored (@cjzero) July 12, 2019The ejection will surely conjure up memories of Allen’s infamous tripping incidents at Duke. For a player attempting to prove he has matured and can contribute in the NBA, this was a silly move.Unless Allen can control his emotions, he won’t be logging many minutes for the Grizzlies this season. That’s good news for opposing players who don’t want to get hurt.last_img read more